CABGOLIN

Cabergoline, an ergot derivative, is a potent dopamine receptor agonist on D₂ receptors. Rat studies show cabergoline has a direct inhibitory effect on pituitary lactotroph cells

DOSTINEX Tablets contain cabergoline, a dopamine receptor agonist. The chemical name for cabergoline is 1-[(6-allylergolin-8β-yl)- carbonyl]-1-[3-(dimethylamino) propyl]-3-ethylurea. Its empirical formula is C₂₆H₃₇N₅O₂ and its molecular weight is 451.62. The structural formula is as follows:

Cabergoline is a white powder soluble in ethyl alcohol, chloroform, and N, N-dimethylformamide (DMF); slightly soluble in 0.1N hydrochloric acid; very slightly soluble in n-hexane; and insoluble in water.

DOSTINEX Tablets, for oral administration, contain 0.5 mg of cabergoline. Inactive ingredients consist of leucine, USP, and lactose, NF.